Publications

[1] B. Oronsky, P. Ma, T. R. Reid, P. Cabrales, M. Lybeck, A. Oronsky, N. Oronsky, and C. A. Carter, “Navigating the ‘No Man’s Land’ of TKI-Failed EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC): A Review.,” Neoplasia, vol. 20, no. 1, pp. 92–98, Jan. 2018.

[2] C. Brzezniak, B. Oronsky, J. Trepel, T. A. J. Summers, P. Cabrales, M.-J. Lee, R. Day, S. Jha, S. Caroen, K. Zeman, L. Ferry, C. Harmer, N. Oronsky, M. Lybeck, H. E. Lybeck, J. F. Brown, T. R. Reid, and C. A. Carter, “RRx-001 Priming of PD-1 Inhibition in the Treatment of Small Cell Carcinoma of the Vagina: A Rare Gynecological Tumor.,” Case Rep. Oncol., vol. 10, no. 1, pp. 276–280, 2017.

[3] B. Oronsky, T. R. Reid, C. Larson, C. A. Carter, C. E. Brzezniak, A. Oronsky, and P. Cabrales, “RRx-001 protects against cisplatin-induced toxicities.,” J. Cancer Res. Clin. Oncol., Apr. 2017.

[4] Q. Zhu, S. Salehyar, P. Cabrales, and R. J. Asaro, “Prospects for Human Erythrocyte Skeleton-Bilayer Dissociation during Splenic Flow.,” Biophys. J., vol. 113, no. 4, pp. 900–912, Aug. 2017.

[5] R. Zimmerman, A. G. Tsai, B. Y. Salazar Vazquez, P. Cabrales, A. Hofmann, J. Meier, A. Shander, D. R. Spahn, J. M. Friedman, D. M. Tartakovsky, and M. Intaglietta, “Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity.,” Anesth. Analg., vol. 124, no. 5, pp. 1547–1554, May 2017.

[6] K. Dufu, O. Yalcin, E. S. Y. Ao-Ieong, A. Hutchaleelala, Q. Xu, Z. Li, N. Vlahakis, D. Oksenberg, J. Lehrer-Graiwer, and P. Cabrales, “GBT1118, a potent allosteric modifier of hemoglobin O2 affinity, increases tolerance to severe hypoxia in mice.,” Am. J. Physiol. Heart Circ. Physiol., vol. 313, no. 2, pp. H381–H391, Aug. 2017.

[7] V. P. Jani, S. Mailo, A. Athar, A. Lucas, A. T. Williams, and P. Cabrales, “Blood Quality Diagnostic Device Detects Storage Differences Between Donors.,” IEEE Trans. Biomed. Circuits Syst., vol. 11, no. 6, pp. 1400–1405, Dec. 2017.

[8] P. Cabrales, S. Caroen, A. Oronsky, C. Carter, J. Trepel, T. Summers, T. Reid, N. Oronsky, M. Lybeck, and B. Oronsky, “The macrophage stimulating anti-cancer agent, RRx-001, protects against ischemia-reperfusion injury.,” Expert Rev. Hematol., vol. 10, no. 6, pp. 575–582, Jun. 2017.

[9] D. A. Belcher, U. Banerjee, C. M. Baehr, K. E. Richardson, P. Cabrales, F. Berthiaume, and A. F. Palmer, “Mixtures of tense and relaxed state polymerized human hemoglobin regulate oxygen affinity and tissue construct oxygenation.,” PLoS One, vol. 12, no. 10, p. e0185988, 2017.

[10] V. P. Jani, O. Yalcin, A. T. Williams, M. A. Popovsky, and P. Cabrales, “Rat red blood cell storage lesions in various additive solutions,” Clin. Hemorheol. Microcirc., pp. 1–13, Jun. 2017.

[11] V. P. Jani, A. Jelvani, S. Moges, P. Nacharaju, C. Roche, D. Dantsker, A. Palmer, J. M. Friedman, and P. Cabrales, “Polyethylene Glycol Camouflaged Earthworm Hemoglobin.,” PLoS One, vol. 12, no. 1, p. e0170041, 2017.

[12] B. Oronsky, R. Paulmurugan, K. Foygel, J. Scicinski, S. J. Knox, D. Peehl, H. Zhao, S. Ning, P. Cabrales, T. A. J. Summers, T. R. Reid, W. L. Fitch, M. M. Kim, J. B. Trepel, M.-J. Lee, S. Kesari, N. D. Abrouk, R. M. Day, A. Oronsky, C. M. Ray, and C. A. Carterg, “RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.,” Expert Opin. Investig. Drugs, vol. 26, no. 1, pp. 109–119, Jan. 2017.

[13] A. F. Martucci, A. C. C. F. Abreu Martucci, P. Cabrales, P. do J. Nascimento, M. Intaglietta, A. G. Tsai, and Y. M. M. Castiglia, “Acute kidney function and morphology following topload administration of recombinant hemoglobin solution.,” Artif. cells, nanomedicine, Biotechnol., vol. 45, no. 1, pp. 24–30, Feb. 2017.

[14] E. S. Y. Ao-ieong, A. Williams, V. Jani, and P. Cabrales, “Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic,” Artif. Cells, Nanomedicine, Biotechnol., vol. 0, no. 0, pp. 1–8, Nov. 2016.

[15] B. Oronsky, J. Scicinski, S. Ning, D. Peehl, A. Oronsky, P. Cabrales, M. Bednarski, and S. Knox, “RRx-001, A novel dinitroazetidine radiosensitizer,” Invest. New Drugs, vol. 34, no. 3, pp. 1–7, Jun. 2016.

[16] B. Y. Salazar Vazquez, M. A. Salazar Vazquez, G. Lopez Gutierrez, K. Acosta Rosales, P. Cabrales, F. Vadillo-Ortega, M. Intaglietta, R. Perez Tamayo, and G. W. Schmid-Schonbein, “Control of overweight and obesity in childhood through education in meal time habits. The ‘good manners for a healthy future’ programme.,” Pediatr. Obes., vol. 11, no. 6, pp. 484–490, Dec. 2016.

[17] R. Diaz-Trelles, M. C. Scimia, P. Bushway, D. Tran, A. Monosov, E. Monosov, K. Peterson, S. Rentschler, P. Cabrales, P. Ruiz-Lozano, and M. Mercola, “Notch-independent RBPJ controls angiogenesis in the adult heart.,” Nat. Commun., vol. 7, p. 12088, Jun. 2016.

[18] C. Brzezniak, B. Oronsky, J. Scicinski, S. Caroen, P. Cabrales, N. Dean Abrouk, M. M. Kim, J. F. Brown, T. R. Reid, C. Larson, A. Oronsky, R. Day, A. Degesys, and C. A. Carter, “Conversion of Platinum-Etoposide-Resistant to Sensitive SCLC after Treatment with the Epi-Immunotherapeutic RRx-001: A Case Report.,” Oncol. Res. Treat., vol. 39, no. 11, pp. 720–723, 2016.

[19] C. A. Carter, B. Oronsky, S. Caroen, J. Scicinski, A. Degesys, P. Cabrales, T. R. Reid, and C. Brzezniak, “Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets.,” Case Rep. Oncol., vol. 9, no. 2, pp. 285–289, 2016.

[20] B. Oronsky, J. Scicinski, M. M. Kim, P. Cabrales, M. E. Salacz, C. A. Carter, N. Oronsky, H. Lybeck, M. Lybeck, C. Larson, T. R. Reid, and A. Oronsky, “Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents.,” Biomolecules, vol. 6, no. 3, Jul. 2016.

[21] M. Kar, Y.-R. Vernon Shih, D. O. Velez, P. Cabrales, and S. Varghese, “Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery.,” Biomaterials, vol. 77, pp. 186–197, Jan. 2016.

[22] B. Oronsky, S. Caroen, K. Zeman, M. Quinn, C. Brzezniak, J. Scicinski, P. Cabrales, T. R. Reid, J. B. Trepel, N. D. Abrouk, C. Larson, A. Oronsky, H. E. Lybeck, R. M. Day, and C. A. Carter, “A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001.,” Clin. Med. Insights. Oncol., vol. 10, pp. 105–108, 2016.

[23] Y. Damestani, D. E. Galan-Hoffman, D. Ortiz, P. Cabrales, and G. Aguilar, “Inflammatory response to implantation of transparent nanocrystalline yttria-stabilized zirconia using a dorsal window chamber model.,” Nanomedicine, vol. 12, no. 7, pp. 1757–1763, Oct. 2016.

[24] M. J. Buono and P. Cabrales, “Hyperthermia during exercise - a double-edged sword.,” Temp. (Austin, Tex.), vol. 3, no. 4, pp. 512–513, 2016.

[25] T. Cordes, M. Wallace, A. Michelucci, A. S. Divakaruni, S. C. Sapcariu, C. Sousa, H. Koseki, P. Cabrales, A. N. Murphy, K. Hiller, and C. M. Metallo, “Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.,” J. Biol. Chem., vol. 291, no. 27, pp. 14274–14284, Jul. 2016.

[26] C. A. Carter, B. Schmitz, P. G. Peterson, M. Quinn, A. Degesys, J. Jenkins, B. Oronsky, J. Scicinski, S. Caroen, T. R. Reid, P. Cabrales, and C. Brzezniak, “Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001.,” Case Rep. Oncol., vol. 9, no. 1, pp. 164–170, 2016.

[27] M. H. Fens, P. Cabrales, J. Scicinski, S. K. Larkin, J. H. Suh, F. A. Kuypers, N. Oronsky, M. Lybeck, A. Oronsky, and B. Oronsky, “Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation.,” Med. Oncol., vol. 33, no. 8, p. 85, Aug. 2016.

[28] C. A. Carter, B. T. Oronsky, S. Z. Caroen, J. J. Scicinski, P. Cabrales, T. Reid, A. Degesys, J. Jenkins, and C. Brzezniak, “Partial Response to Platinum Doublets in Refractory EGFR-Positive Non-Small Cell Lung Cancer Patients after RRx-001: Evidence of Episensitization.,” Case Rep. Oncol., vol. 9, no. 1, pp. 62–67, 2016.

[29] B. Oronsky, J. Scicinski, S. Ning, D. Peehl, A. Oronsky, P. Cabrales, M. Bednarski, and S. Knox, “Rockets, radiosensitizers, and RRx-001: an origin story part I.,” Discov. Med., vol. 21, no. 115, pp. 173–180, Mar. 2016.

[30] C. A. Carter, B. Oronsky, S. Caroen, J. Scicinski, P. Cabrales, A. Degesys, and C. Brzezniak, “Partial response to carboplatin in an RRx-001 pretreated patient with EGFR-inhibitor-resistance and T790M-negative NSCLC.,” Respir. Med. case reports, vol. 18, pp. 62–65, 2016.

[31] B. Oronsky, J. Scicinski, T. Reid, A. Oronsky, C. Carter, N. Oronsky, and P. Cabrales, “RRx-001, a novel clinical-stage chemosensitizer, radiosensitizer, and immunosensitizer, inhibits glucose 6-phosphate dehydrogenase in human tumor cells.,” Discov. Med., vol. 21, no. 116, pp. 251–265, Apr. 2016.

[32] P. Azad, H. W. Zhao, P. J. Cabrales, R. Ronen, D. Zhou, O. Poulsen, O. Appenzeller, Y. H. Hsiao, V. Bafna, and G. G. Haddad, “Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge’s disease.,” J. Exp. Med., vol. 213, no. 12, pp. 2729–2744, Nov. 2016.

[33] B. Oronsky, J. Scicinski, P. Cabrales, and A. Minchinton, “RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors.,” Clin. Epigenetics, vol. 8, p. 53, 2016.

[34] P. Cabrales, J. Scicinski, T. Reid, F. Kuypers, S. Larkin, M. Fens, A. Oronsky, and B. Oronsky, “A look inside the mechanistic black box: Are red blood cells the critical effectors of RRx-001 cytotoxicity?,” Med. Oncol., vol. 33, no. 7, p. 63, Jul. 2016.

[35] M. J. Buono, T. Krippes, F. W. Kolkhorst, A. T. Williams, and P. Cabrales, “Increases in core temperature counterbalance effects of haemoconcentration on blood viscosity during prolonged exercise in the heat.,” Exp. Physiol., vol. 101, no. 2, pp. 332–342, Feb. 2016.

[36] C. A. Carter, B. T. Oronsky, S. Z. Caroen, J. J. Scicinski, A. Degesys, M. M. Kim, A. L. Oronsky, H. Lybeck, P. Cabrales, N. Oronsky, T. Reid, J. Roswarski, and C. Brzezniak, “RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets.,” Case Rep. Oncol., vol. 9, no. 1, pp. 171–176, 2016.

[37] T. Reid, B. Oronsky, J. Scicinski, C. L. Scribner, S. J. Knox, S. Ning, D. M. Peehl, R. Korn, M. Stirn, C. A. Carter, A. Oronsky, M. J. Taylor, W. L. Fitch, P. Cabrales, M. M. Kim, H. A. 3rd Burris, C. D. Lao, N. E. D. Abrouk, G. R. Fanger, and J. R. Infante, “Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study.,” Lancet. Oncol., vol. 16, no. 9, pp. 1133–1142, Sep. 2015.

[38] P. Cabrales, D. Ortiz, and J. M. Friedman, “NO supplementation for transfusion medicine and cardiovascular applications.,” Futur. Sci. OA, vol. 1, no. 1, 2015.

[39] A. G. Tsai, P. Cabrales, M. A. Young, R. M. Winslow, and M. Intaglietta, “Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia.,” Artif. cells, nanomedicine, Biotechnol., vol. 43, no. 1, pp. 10–17, Feb. 2015.

[40] C. A. Carter, A. Degesys, B. Oronsky, J. Scicinski, S. Z. Caroen, A. L. Oronsky, T. Reid, P. Cabrales, and J. Roswarski, “Flushing Out Carcinoid Syndrome: Beneficial Effect of the Anticancer Epigenetic Agent RRx-001 in a Patient with a Treatment-Refractory Neuroendocrine Tumor.,” Case Rep. Oncol., vol. 8, no. 3, pp. 461–465, 2015.

[41] C. J. Roche, A. Talwar, A. F. Palmer, P. Cabrales, G. Gerfen, and J. M. Friedman, “Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties.,” J. Biol. Chem., vol. 290, no. 1, pp. 99–117, Jan. 2015.

[42] O. Yalcin, B. Oronsky, L. J. M. Carvalho, F. A. Kuypers, J. Scicinski, and P. Cabrales, “From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria.,” Malar. J., vol. 14, p. 218, May 2015.

[43] P. Anandan, D. Ortiz, M. Intaglietta, P. J. Cabrales, and M. Bucolo, “Red blood cells flows in rectilinear microfluidic chip.,” Conf. Proc. ... Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. IEEE Eng. Med. Biol. Soc. Annu. Conf., vol. 2015, pp. 3225–3228, 2015.

[44] T. Stobdan, D. Zhou, E. Ao-Ieong, D. Ortiz, R. Ronen, I. Hartley, Z. Gan, A. D. McCulloch, V. Bafna, P. Cabrales, and G. G. Haddad, “Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.,” Proc. Natl. Acad. Sci. U. S. A., vol. 112, no. 33, pp. 10425–10430, Aug. 2015.

[45] C. Brouse, D. Ortiz, Y. Su, B. Oronsky, J. Scicinski, and P. Cabrales, “Impact of hemoglobin nitrite to nitric oxide reductase on blood transfusion for resuscitation from hemorrhagic shock.,” Asian J. Transfus. Sci., vol. 9, no. 1, pp. 55–60, 2015.

[46] O. Yalcin, D. Ortiz, A. G. Tsai, P. C. Johnson, and P. Cabrales, “Microhemodynamic aberrations created by transfusion of stored blood,” Transfusion, vol. 54, no. 4, pp. 1015–1027, Apr. 2014.

[47] S. Chatpun and P. Cabrales, “Nitric oxide synthase inhibition attenuates cardiac response to hemodilution with viscogenic plasma expander.,” Korean Circ. J., vol. 44, no. 2, pp. 105–112, Mar. 2014.

[48] B. Y. Salazar Vazquez, M. A. Salazar Vazquez, A. Chavez-Negrete, G. Escobedo, P. Cabrales, S. Subramaniam, M. Intaglietta, and R. Perez-Tamayo, “Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women.,” Vasc. Health Risk Manag., vol. 10, pp. 271–277, 2014.

[49] C. Liong, D. Ortiz, E. Ao-ieong, M. S. Navati, J. M. Friedman, and P. Cabrales, “Localized increase of tissue oxygen tension by magnetic targeted drug delivery.,” Nanotechnology, vol. 25, no. 26, p. 265102, Jul. 2014.

[50] D. Ortiz, M. Barros, S. Yan, and P. Cabrales, “Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood.,” Am. J. Emerg. Med., vol. 32, no. 3, pp. 248–255, Mar. 2014.

[51] H. L. Mooij, P. Cabrales, S. J. Bernelot Moens, D. Xu, S. D. Udayappan, A. G. Tsai, M. A. J. van der Sande, E. de Groot, M. Intaglietta, J. J. P. Kastelein, G. M. Dallinga-Thie, J. D. Esko, E. S. Stroes, and M. Nieuwdorp, “Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function.,” J. Am. Heart Assoc., vol. 3, no. 6, p. e001274, Dec. 2014.

[52] C. Castro, D. Ortiz, A. F. Palmer, and P. Cabrales, “Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin.,” Minerva Anestesiol., vol. 80, no. 5, pp. 537–546, May 2014.

[53] A. G. Tsai, B. Y. Salazar Vazquez, P. Cabrales, E. B. Kistler, D. M. Tartakovsky, S. Subramaniam, S. A. Acharya, and M. Intaglietta, “Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies.,” J. Funct. Biomater., vol. 5, no. 4, pp. 232–245, Oct. 2014.

[54] M. Tar, P. Cabrales, M. Navati, B. Adler, P. Nacharaju, A. J. Friedman, J. Friedman, and K. P. Davies, “Topically applied NO-releasing nanoparticles can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy.,” J. Sex. Med., vol. 11, no. 12, pp. 2903–2914, Dec. 2014.

[55] D. Ortiz, J. C. Briceno, and P. Cabrales, “Microhemodynamic parameters quantification from intravital microscopy videos.,” Physiol. Meas., vol. 35, no. 3, pp. 351–367, Mar. 2014.

[56] S. Chatpun, P. Nacharaju, and P. Cabrales, “Improving cardiac function with new-generation plasma volume expanders.,” Am. J. Emerg. Med., vol. 31, no. 1, pp. 54–63, Jan. 2013.

[57] D. M. Vásquez, D. Ortiz, O. a. Alvarez, J. C. Briceño, P. Cabrales, M. V Diana, D. Ortiz, J. C. Brice, P. Cabrales, D. M. Vasquez, D. Ortiz, O. a. Alvarez, J. C. Briceno, and P. Cabrales, “Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood,” Biotechnol. Prog., vol. 29, no. i, pp. 796–807, 2013.

[58] P. Cabrales, Y. C. Martins, P. K. Ong, G. M. Zanini, J. A. Frangos, and L. J. M. Carvalho, “Cerebral tissue oxygenation impairment during experimental cerebral malaria.,” Virulence, vol. 4, no. 8, pp. 686–97, Nov. 2013.

[59] M. Ju, S. S. Ye, H. T. Low, J. Zhang, P. Cabrales, H. L. Leo, and S. Kim, “Effect of deformability difference between two erythrocytes on their aggregation.,” Phys. Biol., vol. 10, no. 3, p. 36001, Jun. 2013.

[60] P. K. Ong, B. Melchior, Y. C. Martins, A. Hofer, P. Orjuela-Sanchez, P. Cabrales, G. M. Zanini, J. A. Frangos, and L. J. M. Carvalho, “Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria.,” PLoS Pathog., vol. 9, no. 6, p. e1003444, 2013.

[61] D. Ortiz, P. Cabrales, and J. C. Briceno, “Transport of nitric oxide by perfluorocarbon emulsion.,” Biotechnol. Prog., vol. 29, no. 6, pp. 1565–1572, 2013.

[62] B. Namgung, M. Ju, P. Cabrales, and S. Kim, “Two-phase model for prediction of cell-free layer width in blood flow.,” Microvasc. Res., vol. 85, pp. 68–76, Jan. 2013.

[63] C. M. Hightower, B. Y. Salazar Vazquez, P. Cabrales, A. G. Tsai, S. A. Acharya, and M. Intaglietta, “Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage.,” Transfusion, vol. 53, no. 1, pp. 49–59, Jan. 2013.

[64] P. Cabrales and J. M. Friedman, “HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species.,” Antioxid. Redox Signal., vol. 18, no. 17, pp. 2284–2297, Jun. 2013.

[65] P. Cabrales, “Examining and mitigating acellular hemoglobin vasoactivity.,” Antioxid. Redox Signal., vol. 18, no. 17, pp. 2329–2341, Jun. 2013.

[66] J. Martini, P. Cabrales, D. Fries, M. Intaglietta, and A. G. Tsai, “Effects of fibrinogen concentrate after shock/resuscitation: a comparison between in vivo microvascular clot formation and thromboelastometry*.,” Crit. Care Med., vol. 41, no. 11, pp. e301-8, Nov. 2013.

[67] P. Cabrales and M. Intaglietta, “Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids.,” ASAIO J., vol. 59, no. 4, pp. 337–354, 2013.

[68] S. Chatpun and P. Cabrales, “Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander.,” Life Sci., vol. 90, no. 1–2, pp. 39–46, Jan. 2012.

[69] K. Sriram, A. G. Tsai, P. Cabrales, F. Meng, S. a. Acharya, D. M. Tartakovsky, and M. Intaglietta, “PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning.,” Am. J. Physiol. Heart Circ. Physiol., vol. 302, no. 12, pp. H2489-97, Jun. 2012.

[70] G. M. Zanini, Y. C. Martins, P. Cabrales, J. A. Frangos, and L. J. M. Carvalho, “S-nitrosoglutathione prevents experimental cerebral malaria.,” J. Neuroimmune Pharmacol., vol. 7, no. 2, pp. 477–487, Jun. 2012.

[71] P. Cabrales, S. Rameez, and A. F. Palmer, “Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin.,” Curr. Drug Discov. Technol., vol. 9, no. 3, pp. 224–234, Sep. 2012.

[72] K. Sriram, B. Y. Salazar Vazquez, A. G. Tsai, P. Cabrales, M. Intaglietta, and D. M. Tartakovsky, “Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit.,” Am. J. Physiol. Heart Circ. Physiol., vol. 303, no. 9, pp. H1096-106, Nov. 2012.

[73] C. Messmer, O. Yalcin, A. F. Palmer, and P. Cabrales, “Small-volume resuscitation from hemorrhagic shock with polymerized human serum albumin.,” Am. J. Emerg. Med., vol. 30, no. 8, pp. 1336–1346, Oct. 2012.

[74] Y. Zhou, P. Cabrales, and A. F. Palmer, “Simulation of NO and O2 transport facilitated by polymerized hemoglobin solutions in an arteriole that takes into account wall shear stress-induced NO production.,” Biophys. Chem., vol. 162, pp. 45–60, Mar. 2012.

[75] S. A. Landsverk, A. G. Tsai, P. Cabrales, and M. Intaglietta, “Impact of enzymatic degradation of the endothelial glycocalyx on vascular permeability in an awake hamster model.,” Crit. Care Res. Pract., vol. 2012, p. 842545, 2012.

[76] J. Elmer, K. Zorc, S. Rameez, Y. Zhou, P. Cabrales, and A. F. Palmer, “Hypervolemic infusion of Lumbricus terrestris erythrocruorin purified by tangential-flow filtration.,” Transfusion, vol. 52, no. 8, pp. 1729–1740, Aug. 2012.

[77] P. Nacharaju, C. Tuckman-Vernon, K. E. Maier, J. Chouake, A. Friedman, P. Cabrales, and J. M. Friedman, “A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response.,” Nitric oxide Biol. Chem., vol. 27, no. 3, pp. 150–160, Oct. 2012.

[78] C. Messmer, P. Cabrales, and M. Intaglietta, “Effects of acute anemia and hyperoxia on oxygen distribution.,” Adv. Exp. Med. Biol., vol. 737, pp. 213–218, 2012.

[79] O. Yalcin and P. Cabrales, “Increased hemoglobin O2 affinity protects during acute hypoxia.,” Am. J. Physiol. Heart Circ. Physiol., vol. 303, no. 3, pp. H271-81, Aug. 2012.

[80] J. Elmer, A. F. Palmer, and P. Cabrales, “Oxygen delivery during extreme anemia with ultra-pure earthworm hemoglobin,” Life Sci., vol. 91, no. 17–18, pp. 852–859, Oct. 2012.

[81] S. Chatpun and P. Cabrales, “Cardiac systolic function recovery after hemorrhage determines survivability during shock.,” J. Trauma, vol. 70, no. 4, pp. 787–793, 2011.

[82] N. R. Villela, A. G. Tsai, P. Cabrales, and M. Intaglietta, “Improved resuscitation from hemorrhagic shock with Ringer’s lactate with increased viscosity in the hamster window chamber model.,” J. Trauma, vol. 71, no. 2, pp. 418–424, Aug. 2011.

[83] O. Yalcin, Q. Wang, P. C. Johnson, A. F. Palmer, and P. Cabrales, “Plasma expander viscosity effects on red cell-free layer thickness after moderate hemodilution.,” Biorheology, vol. 48, no. 5, pp. 277–291, 2011.

[84] P. Nachuraju, A. J. Friedman, J. M. Friedman, and P. Cabrales, “Exogenous nitric oxide prevents cardiovascular collapse during hemorrhagic shock.,” Resuscitation, vol. 82, no. 5, pp. 607–613, May 2011.

[85] G. M. Zanini, P. Cabrales, W. Barkho, J. A. Frangos, and L. J. M. Carvalho, “Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice.,” J. Neuroinflammation, vol. 8, p. 66, Jun. 2011.

[86] P. Cabrales and J. Carlos Briceno, “Delaying blood transfusion in experimental acute anemia with a perfluorocarbon emulsion.,” Anesthesiology, vol. 114, no. 4, pp. 901–911, Apr. 2011.

[87] P. Cabrales, “Nanoengineering bactericidal nitric oxide therapies.,” Virulence, vol. 2, no. 3. United States, pp. 185–187, 2011.

[88] B. Y. Salazar Vazquez, P. Cabrales, A. G. Tsai, and M. Intaglietta, “Nonlinear cardiovascular regulation consequent to changes in blood viscosity.,” Clin. Hemorheol. Microcirc., vol. 49, no. 1–4, pp. 29–36, 2011.

[89] P. Cabrales, G. Han, P. Nacharaju, A. J. Friedman, and J. M. Friedman, “Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide.,” Am. J. Physiol. Heart Circ. Physiol., vol. 300, no. 1, pp. H49-56, Jan. 2011.

[90] P. Cabrales, G. M. Zanini, D. Meays, J. A. Frangos, and L. J. M. Carvalho, “Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.,” J. Infect. Dis., vol. 203, no. 10, pp. 1454–1463, May 2011.

[91] C. M. Hightower, B. Y. Salazar Vazquez, S. Woo Park, K. Sriram, J. Martini, O. Yalcin, A. G. Tsai, P. Cabrales, D. M. Tartakovsky, P. C. Johnson, and M. Intaglietta, “Integration of cardiovascular regulation by the blood/endothelium cell-free layer.,” Wiley Interdiscip. Rev. Syst. Biol. Med., vol. 3, no. 4, pp. 458–470, 2011.

[92] A. F. Palmer, N. Zhang, Y. Zhou, D. R. Harris, and P. Cabrales, “Small-Volume Resuscitation From Hemorrhagic Shock Using High-Molecular-Weight Tense-State Polymerized Hemoglobins,” J. Trauma Inj. Infect. Crit. Care, vol. 71, no. 4, pp. 798–807, 2011.

[93] N. Zhang, Y. Jia, G. Chen, P. Cabrales, and A. F. Palmer, “Biophysical properties and oxygenation potential of high-molecular-weight glutaraldehyde-polymerized human hemoglobins maintained in the tense and relaxed quaternary states.,” Tissue Eng. Part A, vol. 17, no. 7–8, pp. 927–940, 2011.

[94] Y. Zhou, Y. Jia, P. W. Buehler, G. Chen, P. Cabrales, and A. F. Palmer, “Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity.,” Biotechnol. Prog., 2011.

[95] J. Elmer, P. Cabrales, Q. Wang, N. Zhang, and A. F. Palmer, “Synthesis and biophysical properties of polymerized human serum albumin,” Biotechnol. Prog., vol. 27, no. 1, pp. 290–296, Jan. 2011.

[96] S. Chatpun and P. Cabrales, “Effects on cardiac function of a novel low viscosity plasma expander based on polyethylene glycol conjugated albumin.,” Minerva Anestesiol., vol. 77, no. 7, pp. 704–14, Jul. 2011.

[97] P. W. Buehler, Y. Zhou, P. Cabrales, Y. Jia, G. Sun, D. R. Harris, A. G. Tsai, M. Intaglietta, and A. F. Palmer, “Synthesis, Biophysical Properties and Pharmacokinetics of Ultrahigh Molecular Weight Tense and Relaxed State Polymerized Bovine Hemoglobins,” Biomaterials, vol. 31, no. 13, pp. 3723–35, May 2010.

[98] S. Chatpun and P. Cabrales, “Cardiac mechanoenergetic cost of elevated plasma viscosity after moderate hemodilution.,” Biorheology, vol. 47, no. 3–4, pp. 225–37, Jan. 2010.

[99] P. Cabrales, G. M. Zanini, D. Meays, J. A. Frangos, and L. J. M. Carvalho, “Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine.,” Am. J. Pathol., vol. 176, no. 3, pp. 1306–15, Mar. 2010.

[100] P. Cabrales and L. J. M. Carvalho, “Intravital microscopy of the mouse brain microcirculation using a closed cranial window.,” J. Vis. Exp., no. 45, Nov. 2010.

[101] A. G. Tsai, A. Hofmann, P. Cabrales, and M. Intaglietta, “Perfusion vs. oxygen delivery in transfusion with ‘fresh’ and ‘old’ red blood cells: the experimental evidence.,” Transfus. Apher. Sci., vol. 43, no. 1, pp. 69–78, Aug. 2010.

[102] P. Cabrales, “Low oxygen-affinity hemoglobin solution increases oxygenation of partially ischemic tissue during acute anemia.,” J. Am. Coll. Surg., vol. 210, no. 3, pp. 271–279, Mar. 2010.

[103] B. Y. S. Vazquez, J. Martini, A. G. Tsai, P. C. Johnson, P. Cabrales, and M. Intaglietta, “The variability of blood pressure due to small changes of hematocrit.,” Am. J. Physiol. Heart Circ. Physiol., vol. 299, no. 3, pp. H863-7, Sep. 2010.

[104] P. Cabrales, G. Han, C. Roche, P. Nacharaju, A. J. Friedman, and J. M. Friedman, “Sustained release nitric oxide from long-lived circulating nanoparticles.,” Free Radic. Biol. Med., vol. 49, no. 4, pp. 530–538, Aug. 2010.

[105] A. G. Tsai, P. Cabrales, and M. Intaglietta, “The physics of oxygen delivery: facts and controversies.,” Antioxidants & redox signaling, vol. 12, no. 6. United States, pp. 683–691, Mar-2010.

[106] B. Y. Salazar Vazquez, J. Martini, A. Chavez Negrete, A. G. Tsai, S. Forconi, P. Cabrales, P. C. Johnson, and M. Intaglietta, “Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence.,” Clin. Hemorheol. Microcirc., vol. 44, no. 2, pp. 75–85, 2010.

[107] P. Cabrales, F. Meng, and S. A. Acharya, “Tissue oxidative metabolism after extreme hemodilution with PEG-conjugated hemoglobin.,” J. Appl. Physiol., vol. 109, no. 6, pp. 1852–1859, Dec. 2010.

[108] B. Y. S. Vazquez, M. A. S. Vazquez, M. G. Jaquez, A. H. B. Huemoeller, M. Intaglietta, and P. Cabrales, “Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals.,” Clin. Hemorheol. Microcirc., vol. 44, no. 1, pp. 55–61, 2010.

[109] P. Cabrales, Y. Zhou, D. R. Harris, and A. F. Palmer, “Tissue oxygenation after exchange transfusion with ultrahigh-molecular- weight tense-and relaxed-state polymerized bovine hemoglobins,” Am. J. Physiol. Heart Circ. Physiol., vol. 298, no. 3, pp. H1062-71, 2010.

[110] S. Chatpun and P. Cabrales, “Effects of plasma viscosity modulation on cardiac function during moderate hemodilution.,” Asian J. Transfus. Sci., vol. 4, no. 2, pp. 102–8, Jul. 2010.

[111] P. Cabrales and A. G. Tsai, “Will fixing the vasoactivity caused by hemoglobin-based oxygen carriers be enough?,” Critical care medicine, vol. 37, no. 6. United States, pp. 2125–2126, Jun-2009.

[112] M. A. S. Vazquez, B. Y. S. Vazquez, M. Intaglietta, and P. Cabrales, “Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein.,” Vasc. Health Risk Manag., vol. 5, no. 1, pp. 62–65, 2009.

[113] J. O. Lundberg, M. T. Gladwin, A. Ahluwalia, N. Benjamin, N. S. Bryan, A. Butler, P. Cabrales, A. Fago, M. Feelisch, P. C. Ford, B. A. Freeman, M. Frenneaux, J. Friedman, M. Kelm, C. G. Kevil, D. B. Kim-Shapiro, A. V Kozlov, J. R. J. Lancaster, D. J. Lefer, K. McColl, K. McCurry, R. P. Patel, J. Petersson, T. Rassaf, V. P. Reutov, G. B. Richter-Addo, A. Schechter, S. Shiva, K. Tsuchiya, E. E. van Faassen, A. J. Webb, B. S. Zuckerbraun, J. L. Zweier, and E. Weitzberg, “Nitrate and nitrite in biology, nutrition and therapeutics.,” Nature chemical biology, vol. 5, no. 12. United States, pp. 865–869, Dec-2009.

[114] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters.,” Shock, vol. 31, no. 3, pp. 300–307, Mar. 2009.

[115] B. Y. S. Vazquez, M. A. S. Vazquez, M. Intaglietta, U. de Faire, B. Fagrell, and P. Cabrales, “Hematocrit and mean arterial blood pressure in pre- and postmenopause women.,” Vasc. Health Risk Manag., vol. 5, no. 2, pp. 483–488, 2009.

[116] P. Cabrales, “Low dose nitrite enhances perfusion after fluid resuscitation from hemorrhagic shock.,” Resuscitation, vol. 80, no. 12, pp. 1431–1436, Dec. 2009.

[117] F. Meng, B. N. Manjula, A. G. Tsai, P. Cabrales, M. Intaglietta, P. K. Smith, M. Prabhakaran, and S. A. Acharya, “Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts.,” Protein J., vol. 28, no. 5, pp. 199–212, Jun. 2009.

[118] N. R. Villela, P. Cabrales, A. G. Tsai, and M. Intaglietta, “Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model.,” Shock, vol. 31, no. 6, pp. 645–652, Jun. 2009.

[119] B. Y. Salazar Vazquez, J. Martini, A. Chavez Negrete, P. Cabrales, A. G. Tsai, and M. Intaglietta, “Microvascular benefits of increasing plasma viscosity and maintaining blood viscosity: counterintuitive experimental findings.,” Biorheology, vol. 46, no. 3, pp. 167–179, 2009.

[120] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Exogenous nitric oxide induces protection during hemorrhagic shock.,” Resuscitation, vol. 80, no. 6, pp. 707–712, Jun. 2009.

[121] P. Cabrales, G. Sun, Y. Zhou, D. R. Harris, A. G. Tsai, M. Intaglietta, and A. F. Palmer, “Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction.,” J. Appl. Physiol., vol. 107, no. 5, pp. 1548–58, Nov. 2009.

[122] P. Cabrales, A. G. Tsai, K. Ananda, S. A. Acharya, and M. Intaglietta, “Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin.,” Resuscitation, vol. 79, no. 1, pp. 139–146, Oct. 2008.

[123] T. Gardeazabal, M. Cabrera, P. Cabrales, M. Intaglietta, and J. C. Briceno, “Oxygen transport during hemodilution with a perfluorocarbon-based oxygen carrier: effect of altitude and hyperoxia.,” J. Appl. Physiol., vol. 105, no. 2, pp. 588–594, Aug. 2008.

[124] P. Cabrales, M. A. Salazar Vazquez, B. Salazar Vazquez, M. Rodriguez-Moran, M. Intaglietta, and F. Guerrero-Romeros, “Blood pressure reduction due to hemoglobin glycosylation in type 2 diabetic patients.,” Vasc. Health Risk Manag., vol. 4, no. 4, pp. 917–922, 2008.

[125] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Balance between vasoconstriction and enhanced oxygen delivery.,” Transfusion, vol. 48, no. 10, pp. 2087–2095, Oct. 2008.

[126] J. Martini, P. Cabrales, A. K, S. A. Acharya, M. Intaglietta, and A. G. Tsai, “Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective.,” Crit. Care, vol. 12, no. 2, p. R54, 2008.

[127] B. Y. Salazar Vazquez, R. Wettstein, P. Cabrales, A. G. Tsai, and M. Intaglietta, “Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation.,” Biochim. Biophys. Acta, vol. 1784, no. 10, pp. 1421–1427, Oct. 2008.

[128] B. Y. Salazar Vazquez, M. A. Salazar Vazquez, V. C. Venzor, A. C. Negrete, P. Cabrales, J. S. Diaz, and M. Intaglietta, “Increased hematocrit and reduced blood pressure following control of glycemia in diabetes.,” Clin. Hemorheol. Microcirc., vol. 38, no. 1, pp. 57–64, 2008.

[129] B. Y. Salazar Vazquez, P. Cabrales, A. G. Tsai, P. C. Johnson, and M. Intaglietta, “Lowering of blood pressure by increasing hematocrit with non nitric oxide scavenging red blood cells.,” Am. J. Respir. Cell Mol. Biol., vol. 38, no. 2, pp. 135–142, Feb. 2008.

[130] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction.,” Am. J. Physiol. Heart Circ. Physiol., vol. 295, no. 5, pp. H2212-8, Nov. 2008.

[131] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock.,” Resuscitation, vol. 77, no. 3, pp. 379–386, Jun. 2008.

[132] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia.,” Am. J. Respir. Cell Mol. Biol., vol. 38, no. 3, pp. 354–61, Mar. 2008.

[133] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes.,” Shock, vol. 28, no. 4, pp. 461–467, Oct. 2007.

[134] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?,” Shock, vol. 27, no. 4, pp. 380–389, Apr. 2007.

[135] N. Hangai-Hoger, A. G. Tsai, P. Cabrales, M. Suematsu, and M. Intaglietta, “Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution.,” Crit. Care Med., vol. 35, no. 4, pp. 1123–1132, Apr. 2007.

[136] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Perfluorocarbon in microcirculation during ischemia reperfusion.,” J. Am. Coll. Surg., vol. 204, no. 2, pp. 225–235, Feb. 2007.

[137] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Hemorrhagic shock resuscitation with carbon monoxide saturated blood.,” Resuscitation, vol. 72, no. 2, pp. 306–318, Feb. 2007.

[138] P. Cabrales, B. Y. S. Vazquez, A. G. Tsai, and M. Intaglietta, “Microvascular and capillary perfusion following glycocalyx degradation.,” J. Appl. Physiol., vol. 102, no. 6, pp. 2251–2259, Jun. 2007.

[139] P. Cabrales, “Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia.,” Am. J. Physiol. Heart Circ. Physiol., vol. 293, no. 2, pp. H1206-15, Aug. 2007.

[140] P. Cabrales, M. Intaglietta, and A. G. Tsai, “Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity.,” Resuscitation, vol. 75, no. 1, pp. 124–134, Oct. 2007.

[141] N. Hangai-Hoger, A. G. Tsai, P. Cabrales, and M. Intaglietta, “Terminal lymphatics: the potential ‘lethal corner’ in the distribution of tissue pO2.,” Lymphat. Res. Biol., vol. 5, no. 3, pp. 159–168, 2007.

[142] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin.,” Antioxid. Redox Signal., vol. 9, no. 3, pp. 375–384, Mar. 2007.

[143] T. Frietsch, M. Gassmann, G. Groth, K. F. Waschke, J. Vogel, P. Cabrales, P. Vajkoczi, A. Dorn-Beineke, M. Intaglietta, and H. Kerger, “Excessive erythrocytosis does not elevate capillary oxygen delivery in subcutaneous mouse tissue.,” Microcirculation, vol. 14, no. 2, pp. 111–123, Feb. 2007.

[144] A. G. Tsai, P. Cabrales, P. C. Johnson, and M. Intaglietta, “New phosphorescence quenching oxygen measurements technique yields unusual tissue and plasma PO2 distributions.,” Journal of applied physiology (Bethesda, Md. : 1985), vol. 102, no. 5. United States, p. 2081–2; author reply 2083, May-2007.

[145] P. Cabrales and M. Intaglietta, “Time-dependant oxygen partial pressure in capillaries and tissue in the hamster window chamber model.,” Antioxid. Redox Signal., vol. 9, no. 7, pp. 845–853, Jul. 2007.

[146] A. G. Tsai, B. Friesenecker, P. Cabrales, N. Hangai-Hoger, and M. Intaglietta, “The vascular wall as a regulator of tissue oxygenation.,” Curr. Opin. Nephrol. Hypertens., vol. 15, no. 1, pp. 67–71, Jan. 2006.

[147] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia.,” J. Appl. Physiol., vol. 100, no. 4, pp. 1181–1187, Apr. 2006.

[148] N. Hangai-Hoger, P. Nacharaju, B. N. Manjula, P. Cabrales, A. G. Tsai, S. A. Acharya, and M. Intaglietta, “Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia.,” Crit. Care Med., vol. 34, no. 1, pp. 108–117, Jan. 2006.

[149] A. G. Tsai and P. Cabrales, “Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored?,” Critical care medicine, vol. 34, no. 5. United States, pp. 1566–1567, May-2006.

[150] J. Martini, B. Carpentier, A. Chavez Negrete, P. Cabrales, A. G. Tsai, and M. Intaglietta, “Beneficial effects due to increasing blood and plasma viscosity.,” Clin. Hemorheol. Microcirc., vol. 35, no. 1–2, pp. 51–57, 2006.

[151] P. Cabrales, A. G. Tsai, P. C. Johnson, and M. Intaglietta, “Oxygen release from arterioles with normal flow and no-flow conditions.,” J. Appl. Physiol., vol. 100, no. 5, pp. 1569–1576, May 2006.

[152] P. Cabrales, J. Martini, M. Intaglietta, and A. G. Tsai, “Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity.,” Am. J. Physiol. Heart Circ. Physiol., vol. 291, no. 2, pp. H581-90, Aug. 2006.

[153] J. Martini, P. Cabrales, A. G. Tsai, and M. Intaglietta, “Mechanotransduction and the homeostatic significance of maintaining blood viscosity in hypotension, hypertension and haemorrhage.,” J. Intern. Med., vol. 259, no. 4, pp. 364–372, Apr. 2006.

[154] J. Martini, A. G. Tsai, P. Cabrales, P. C. Johnson, and M. Intaglietta, “Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model.,” Am. J. Physiol. Heart Circ. Physiol., vol. 291, no. 1, pp. H310-7, Jul. 2006.

[155] P. Cabrales and A. G. Tsai, “Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions.,” Am. J. Physiol. Heart Circ. Physiol., vol. 291, no. 5, pp. H2445-52, Nov. 2006.

[156] M. Intaglietta, P. Cabrales, and A. G. Tsai, “Microvascular perspective of oxygen-carrying and -noncarrying blood substitutes.,” Annu. Rev. Biomed. Eng., vol. 8, pp. 289–321, 2006.

[157] A. G. Tsai, P. Cabrales, B. N. Manjula, S. A. Acharya, R. M. Winslow, and M. Intaglietta, “Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.,” Blood, vol. 108, no. 10, pp. 3603–10, Nov. 2006.

[158] A. G. Tsai, P. Cabrales, and M. Intaglietta, “Blood viscosity: a factor in tissue survival?,” Critical care medicine, vol. 33, no. 7. United States, pp. 1662–1663, Jul-2005.

[159] H. Sakai, P. Cabrales, A. G. Tsai, E. Tsuchida, and M. Intaglietta, “Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model.,” Am. J. Physiol. Heart Circ. Physiol., vol. 288, no. 6, pp. H2897-903, Jun. 2005.

[160] P. Cabrales, H. Sakai, A. G. Tsai, S. Takeoka, E. Tsuchida, and M. Intaglietta, “Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution.,” Am. J. Physiol. Heart Circ. Physiol., vol. 288, no. 4, pp. H1885-92, Apr. 2005.

[161] P. Cabrales, A. G. Tsai, R. M. Winslow, and M. Intaglietta, “Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin.,” Am. J. Physiol. Heart Circ. Physiol., vol. 289, no. 6, pp. H2392-400, Dec. 2005.

[162] N. Hangai-Hoger, A. G. Tsai, B. Friesenecker, P. Cabrales, and M. Intaglietta, “Microvascular oxygen delivery and consumption following treatment with verapamil.,” Am. J. Physiol. Heart Circ. Physiol., vol. 288, no. 4, pp. H1515-20, Apr. 2005.

[163] A. G. Tsai, C. Acero, P. R. Nance, P. Cabrales, J. A. Frangos, D. G. Buerk, and M. Intaglietta, “Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion.,” Am. J. Physiol. Heart Circ. Physiol., vol. 288, no. 4, pp. H1730-9, Apr. 2005.

[164] A. G. Tsai, P. Cabrales, P. C. Johnson, M. Intaglietta, A. S. Golub, and R. N. Pittman, “Effect of oxygen consumption by measuring method on PO2 transients associated with the passage of erythrocytes in capillaries of rat mesentery.,” American journal of physiology. Heart and circulatory physiology, vol. 289, no. 4. United States, p. H1777; author reply H1778-9, Oct-2005.

[165] P. Cabrales, M. Intaglietta, and A. G. Tsai, “Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding.,” Shock, vol. 23, no. 6, pp. 549–555, Jun. 2005.

[166] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution.,” Am. J. Physiol. Heart Circ. Physiol., vol. 288, no. 4, pp. H1708-16, Apr. 2005.

[167] P. Cabrales, A. G. Tsai, R. M. Winslow, and M. Intaglietta, “Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure.,” Am. J. Physiol. Heart Circ. Physiol., vol. 288, no. 5, pp. H2146-53, May 2005.

[168] P. Cabrales, P. Nacharaju, B. N. Manjula, A. G. Tsai, S. a Acharya, and M. Intaglietta, “Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders.,” Shock, vol. 24, no. 1, pp. 66–73, 2005.

[169] P. Cabrales, A. G. Tsai, J. A. Frangos, and M. Intaglietta, “Role of endothelial nitric oxide in microvascular oxygen delivery and consumption.,” Free Radic. Biol. Med., vol. 39, no. 9, pp. 1229–37, Nov. 2005.

[170] J. C. Briceno, P. Cabrales, A. G. Tsai, and M. Intaglietta, “Radial displacement of red blood cells during hemodilution and the effect on arteriolar oxygen profile.,” Am. J. Physiol. Heart Circ. Physiol., vol. 286, no. 3, pp. H1223-8, Mar. 2004.

[171] N. Hangai-Hoger, P. Cabrales, J. C. Briceno, A. G. Tsai, and M. Intaglietta, “Microlymphatic and tissue oxygen tension in the rat mesentery.,” Am. J. Physiol. Heart Circ. Physiol., vol. 286, no. 3, pp. H878-83, Mar. 2004.

[172] A. G. Tsai, P. Cabrales, and M. Intaglietta, “Oxygen-carrying blood substitutes: a microvascular perspective.,” Expert Opin. Biol. Ther., vol. 4, no. 7, pp. 1147–1157, Jul. 2004.

[173] R. Wettstein, P. Cabrales, D. Erni, A. G. Tsai, R. M. Winslow, and M. Intaglietta, “Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin.,” Shock, vol. 22, no. 4, pp. 351–357, Oct. 2004.

[174] P. Cabrales, A. G. Tsai, J. A. Frangos, J. C. Briceno, and M. Intaglietta, “Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons.,” Am. J. Physiol. Heart Circ. Physiol., vol. 287, no. 1, pp. H320-30, Jul. 2004.

[175] A. G. Tsai, P. Cabrales, and M. Intaglietta, “Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions.,” Transfusion, vol. 44, no. 11, pp. 1626–1634, Nov. 2004.

[176] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock.,” Shock, vol. 22, no. 5, pp. 431–437, Nov. 2004.

[177] P. Cabrales, N. D. Kanika, B. N. Manjula, A. G. Tsai, S. a Acharya, and M. Intaglietta, “Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber.,” Am. J. Physiol. Heart Circ. Physiol., vol. 287, no. 4, pp. H1609-17, 2004.

[178] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin.,” Am. J. Physiol. Heart Circ. Physiol., vol. 287, no. 6, pp. H2825-33, 2004.

[179] P. Cabrales, A. G. Tsai, and M. Intaglietta, “Microvascular pressure and functional capillary density in extreme hemodilution with low- and high-viscosity dextran and a low-viscosity Hb-based O2 carrier.,” Am. J. Physiol. Heart Circ. Physiol., vol. 287, no. 1, pp. H363-73, Jul. 2004.

[180] A. G. Tsai, P. Cabrales, N. Hangai-Hoger, and M. Intaglietta, “Oxygen Distribution and Respiration by the Microcirculation,” Antioxidants Redox Signal., vol. 6, no. 6, pp. 1011–1018, 2004.

[181] A. G. Tsai, P. Cabrales, R. M. Winslow, and M. Intaglietta, “Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia.,” Am. J. Physiol. Heart Circ. Physiol., vol. 285, no. 4, pp. H1537-45, Oct. 2003.

[182] P. Cabrales, C. Acero, M. Intaglietta, and A. G. Tsai, “Measurement of the cardiac output in small animals by thermodilution.,” Microvasc. Res., vol. 66, no. 2, pp. 77–82, Sep. 2003.

[183] E. Saldivar, P. Cabrales, A. G. Tsai, and M. Intaglietta, “Microcirculatory changes during chronic adaptation to hypoxia.,” Am. J. Physiol. Heart Circ. Physiol., vol. 285, no. 5, pp. H2064-71, Nov. 2003.