Most Recent Publications
Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease
MJ Lucero, C Lisk, D Swindle, F Cendali, S Setua, K Thangaraju, A Khan, Biomedicine & Pharmacotherapy 192, 118595. 2025
Hemodynamics and Microvascular Oxygenation Under Intermittent Hypoxia to Simulate Sleep Apnea. P Cabrales. 2025
Sex-specific glomerular filtration rate changes in response to acute hemoglobin exposure. D Lucas, CR Muller, C Munoz, Q O’Boyle, AF Palmer, P Cabrales. Biomedicine & Pharmacotherapy 191, 118461. 2025
In vivo itaconate tracing reveals degradation pathway and turnover kinetics. HF Willenbockel, AT Williams, A Lucas, MB Reynolds, E Joulia, ...Nature Metabolism, 1-10 6 2025
Microvascular Consequences of Methemoglobin Compared to Reduced Hemoglobin in the Microcirculation. J Martinez, C Munoz, D Lucas, C Muller, K Govender, X Gu, AF Palmer, P Cabrales. Microcirculation 32 (6), e70022 2 2025
PEGylation of polymerized albumin retains colloid osmotic pressure: Towards an enhanced potential plasma substitute. A Abdalbaqi, A Yahya, K Govender, C Muñoz, GS Van Moer, D Lucas, P Cabrales. Biotechnology Progress, e70054 1 2025
Gender Differences in Renal Toxicity Induced by Hemoglobin and the Protective Role of Estrogen. D Lucas, P Cabrales. Physiology 40 (S1), 1443 2025
Effect of Molecular Size on the Systemic and Microcirculatory Response to Polymerized Based Hemoglobin-Based Oxygen Carriers. J Martinez, C Munoz, D Lucas, I Garcia, Y Aguirre, CR Muller, A Palmer, P Cabrales. Physiology 40 (S1), 1752 2025
Microvascular oxygenation during simulated sleep apneaUsing Hyperspectral Imaging. C Munoz, D Lucas, J Martinez, P Cabrales. Physiology 40 (S1), 1762 2025
Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice. S Lu, MA Khan, S Setua, Q O'Boyle, K Thangaraju, P Cabrales Biotechnology and Bioengineering 1 2025
Biopreservation and reversal of oxidative injury during blood storage by a novel curcumin-based gel formulation. W Hicks, S Jana, T Kassa, R Prince, P Cabrales, J Friedman, AI Alayash Scientific Reports 14 (1), 31441 3 2024
Characterization of Reduced Viscoelasticity in Sickle Cell Disease Mouse Red Blood Cells Using Parallel Plate Rheometry. NS Ung, CJ Munoz, K Govender, D Lucas, CR Muller, J Martinez, S Gopal, P Cabrales Blood 144, 5293 2024
Mitigating hemoglobin‐induced nephropathy: ApoHb‐hp protection of podocytes. D Lucas, C Munoz, Q O'Boyle, IS Pires, AF Palmer, P Cabrales. Physiological Reports 12 (22), e70132 3 2024.
Tangential flow filtration facilitated fractionation of polymerized human serum albumin: Insights into the effects of molecular size on biophysical properties A Abdalbaqi, A Yahya, K Govender, C Muñoz, GSV Moer, D Lucas, P Cabrales. Biotechnology Progress 40 (6), e3500 1 2024
Coadministration of PEGylated apohemoglobin and haptoglobin can limit vascular dysfunction in the microcirculation and prevent acute inflammation. CJ Munoz, D Lucas, CR Muller, J Martinez, Q O’Boyle, IS Pires, P Cabrales. Journal of Applied Physiology 137 (4), 934-944 2024
Degree of PEGylatation of Lumbricus terrestris Hemoglobin Improves Microcirculatory Blood Flow but Increases the Rate of Auto-Oxidation. CJ Munoz, D Lucas, CR Muller, A Breton, V Jani, C Savla, AF Palmer, P Cabrales. ACS Applied Bio Materials 7 (8), 5188-5200 2 2024
Novel high molecular weight polymerized hemoglobin in a non-obese model of cardiovascular and metabolic dysfunction. CR Muller, AT Williams, AM Eaker, C Walser, F Dos Santos, P Cabrales. Biomedicine & Pharmacotherapy 176, 116789 1 2024
Chapter The Role of Plasmatic Viscosity. P Cabrales, AG Tsai, J Martini, M Intaglietta. Hemodynamic Monitoring and Fluid Therapy during Surgery, 96 2024
ApoHemoglobin-Haptoglobin protects from hemoglobin induced nephropathy. D Lucas, C Munoz, AF Palmer, P Cabrales. Physiology 39 (S1), 1606 2024
Toxic side-effects of diaspirin cross-linked human hemoglobin are attenuated by the apohemoglobin-haptoglobin complex. CJ Munoz, D Lucas, J Martinez, M Ricario, QT O'Boyle, IS Pires, P Cabrales. Biomedicine & Pharmacotherapy 174, 116569 2 2024
A mathematical model of tissue axial and radial diffusion in the microvasculature for intravascular microscopy and phosphorescence quenching data. VP Jani, VP Jani, C Munoz, P Cabrales. Computers in Biology and Medicine 174, 108406 2024
Hypoxically stored RBC resuscitation in a rat model of traumatic brain injury and severe hemorrhagic shock. CR Muller, V Courelli, K Govender, L Omert, T Yoshida, P Cabrales. Life Sciences 340, 122423 7 2024
High-molecular-weight linear polymers improve microvascular perfusion after extracorporeal circulation. K Govender, C Walser, P Cabrales. Journal of Applied Physiology 136 (1), 213-223 1 2024
Continuous Dosing of Apohemoglobin-Haptoglobin in Beta Thalassemic Mice to Establish Safety and Efficacy. CJ Munoz, D Lucas, CR Muller, J Martinez, K Govender, S Gopal, P Cabrales Blood 142 (Supplement 1), 5227-5227 2023
Investigating the Vasodilatory Effects of Tgpolyhb: A Potential Hemoglobin-Based Oxygen Carrier for Sickle Cell Disease and Thalassemia. CJ Munoz, D Lucas, CR Muller, S Gopal, P Cabrales. Blood 142, 5281. 2023
Preventing Kidney Failure in Hemolytic Anemias with a Novel Heme and Hemoglobin Scavenger. D Lucas, P Cabrales, CJ Munoz, S Gopal, CR Muller. Blood 142, 5231 2023
Changes in oxygen delivery during experimental models of cerebral malaria. VP Jani, AT Williams, L Carvalho, P Cabrales
Experimental Parasitology 254, 108608 2023
Polymerized human hemoglobin with low and high oxygen affinity in trauma models. CR Muller, V Courelli, C Walser, CT Cuddington, SR Wolfe, AF Palmer, P Cabrales. Translational Research 260, 83-92 3 2023
TGF-Β: the apex predator of immune checkpoints. B Oronsky, P Cabrales, B Alizadeh, S Caroen, M Stirn, J Williams. Future Oncology 19 (30), 2013-2015 5 2023
GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. K Dufu, C Alt, S Strutt, J Partridge, T Tang, V Siu, H Liao‐Zou, P Cabrales. British Journal of Haematology 202 (1), 173-183. 16 2023
The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness. RJ Asaro, E Profumo, B Buttari, P Cabrales. International journal of molecular sciences 24 (12), 10382 3 2023
Prony Analysis of Left Ventricle Pressure and Volume. VP Jani, AT Williams, VP Jani, AG Tsai, M Intaglietta, P Cabrales. Medical Engineering & Physics 116, 103987 1 2023
RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist. B Oronsky, L Takahashi, R Gordon, P Cabrales, S Caroen, T Reid. Frontiers in Oncology 13, 1204143 19 2023
PEGylation of Apohemoglobin Haptoglobin Complex reduces Associated Free Stroma Hemoglobin Toxicities. C Munoz, D Lucas, CR Muller, S Gopal, P Cabrales. Physiology 38 (S1), 5734902 2023
Microvascular changes in young hamsters after single heterochronic blood transfusion of one unit of blood. D Lucas, CR Muller, F Dos Santos, P Cabrales. Physiology 38 (S1), 5733981 2023
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues. MT Spang, R Middleton, M Diaz, J Hunter, J Mesfin, A Banka, H Sullivan, ...Nature biomedical engineering 7 (2), 94-109 48 2023
Resuscitation from Hemorrhagic Shock With a Novel Protein Cocktail Restores Microvascular Perfusion and Protects Vital Organs. CJ Munoz, D Lucas, IS Pires, T Cordes, C Muller, K Govender, A Breton, P Cabrales. Shock, 10.1097 2023
RRx-001, a Hypoxic No Donor and NLRP3 Inflammasome Inhibitor, in Phase 3 for the Treatment of Cancer, Cardioprotects Following Acute Myocardial Infarction. P Cabrales, T Reid, S Caroen, B Oronsky. CIRCULATION RESEARCH 131 (12), E184-E184 1 2022
Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme. CJ Munoz, IS Pires, V Jani, S Gopal, AF Palmer, P Cabrales. Biomedicine & Pharmacotherapy 156, 113911 7 2022
Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock. CR Muller, AT Williams, C Walser, AM Eaker, JL Sandoval, P Cabrales. Scientific reports 12 (1), 20480 15 2022
Apohemoglobin-Haptoglobin Complex Prevents Microvascular Dysfunction in Sickle Cell Mice: Potential Therapeutic Approach for Vaso-Occlusive Crisis. CJ Munoz, CR Muller, D Lucas, IS Pires, AF Palmer, S Gopal, P Cabrales. Blood, The Journal of the American Society of Hematology 140 1 2022
Implications of microvascular dysfunction and nitric oxide mediated inflammation in severe COVID-19 infection. VP Jani, CJ Munoz, K Govender, AT Williams, P Cabrales. The American Journal of the Medical Sciences 364 (3), 251-256 5 2022
Hyperspectral wide-field-of-view imaging to study dynamic microcirculatory changes during hypoxia. A Lucas, C Munoz, P Cabrales American Journal of Physiology-Heart and Circulatory Physiology 323 (1), H49-H58 5 2022
The disconnect between extracorporeal circulation and the microcirculation: A review. K Govender, VP Jani, P Cabrales. ASAIO journal 68 (7), 881-889 31 2022
The small molecule NLRP3 inhibitor RRx-001 potentiates regorafenib activity and attenuates regorafenib-induced toxicity in mice bearing human colorectal cancer xenografts. T Reid, B Oronsky, N Abrouk, S Caroen, P Cabrales. American Journal of Cancer Research 12 (4), 1912 9 2022
Nitric oxide releasing nanoparticles reduce inflammation in a small animal model of ARDS. VP Jani, JM Friedman, P Cabrales. Biomedicine & Pharmacotherapy 148, 112705 6 2022
Extracorporeal circulation impairs microcirculation perfusion and organ function. K Govender, P Cabrales. Journal of Applied Physiology 132 (3), 794-810 18 2022
Attenuating ischemia-reperfusion injury with polymerized albumin. DA Belcher, AT Williams, CJ Munoz, CR Muller, C Walser, AF Palmer, P Cabrales. Journal of Applied Physiology 132 (2), 489-496 11 2022
Heme Scavenging with Apohemoglobin-Haptoglobin Complex in Beta Thalassemia Intermedia Improves Anemia and Iron Indices: A Novel Therapeutic Approach CJ Munoz, IS Pires, AF Palmer, P Cabrales, S Gopal Blood 138, 3082 2021
The RBC’s road to ghost and removal: splenic clearance. RJ Asaro, P Cabrales. Blood Advances 5 (21), 4422-4425 4 2021
Vascular priming with RRx-001 to increase the uptake and accumulation of temozolomide and irinotecan in orthotopically implanted gliomas. B Oronsky, T Reid, P Cabrales Journal of Drug Targeting 29 (9), 998-1003 14 2021
Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice. K Dufu, AT Williams, CR Muller, CM Walser, A Lucas, AM Eaker, C Alt, .P Cabrales American Journal of Physiology-Heart and Circulatory Physiology 321 (2 6 2021
Purification and analysis of a protein cocktail capable of scavenging cell‐free hemoglobin, heme, and iron. IS Pires, K Govender, CJ Munoz, AT Williams, QT O'Boyle, C Savla, P Cabrales. Transfusion 61 (6), 1894-1907 9 2021
Discovery of RRx-001, a Myc and CD47 downregulating small molecule with tumor targeted cytotoxicity and healthy tissue cytoprotective properties in clinical development. B Oronsky, XN Guo, XH Wang, P Cabrales, D Sher, L Cannizzo, B Wardle Journal of medicinal chemistry 64 (11), 7261-7271 44 2021
Red blood cells: Tethering, vesiculation, and disease in micro-vascular flow. RJ Asaro, P Cabrales Diagnostics 11 (6), 971 11 2021
Polymerized albumin restores impaired hemodynamics in endotoxemia and polymicrobial sepsis. DA Belcher, AT Williams, AF Palmer, P Cabrales. Scientific reports 11 (1), 10834 13 2021
RRx-001 increases erythrocyte preferential adhesion to the tumor vasculature. VP Jani, R Asaro, B Oronsky, P Cabrales. International journal of molecular sciences 22 (9), 4713 6 2021
RRx-001, a downregulator of the CD47-SIRPα checkpoint pathway, does not cause anemia or thrombocytopenia. B Oronsky, P Cabrales, S Caroen, X Guo, C Scribner, A Oronsky, TR Reid Expert Opinion on Drug Metabolism & Toxicology 17 (4), 355-357 15 2021
High fat high sucrose diet-induced dyslipidemia in guinea pigs. CR Muller, AT Williams, AM Eaker, F Dos Santos, AF Palmer, P Cabrales. Journal of Applied Physiology 130 (4), 1226-1234 11 2021
Application of negative tissue interstitial pressure improves functional capillary density after hemorrhagic shock in the absence of volume resuscitation. VP Jani, VP Jani, CJ Munoz, K Govender, AT Williams, P Cabrales. Physiological Reports 9 (5), e14783 5 2021
Negative pressure increases microvascular perfusion during severe hemorrhagic shock. K Govender, CJ Munoz, AT Williams, P Cabrales. Microvascular research 134, 104125 7 2021
Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin. CR Muller, V Courelli, A Lucas, AT Williams, JB Li, F Dos Santos, P Cabrales Scientific reports 11 (1), 2509 31 2021
Red Blood Cells: Tethering, Vesiculation, and Disease in Micro-Vascular Flow. Diagnostics 2021, 11, 971 RJ Asaro, P Cabrales
In small cell lung cancer patients treated with RRx-001, a downregulator of CD47, decreased expression of PD-L1 on circulating tumor cells significantly correlates Y Tomita, B Oronsky, N Abrouk, P Cabrales, TR Reid, MJ Lee, A Yuno, Translational Lung Cancer Research 10 (1), 274 20 2021
Safety profile of high molecular weight polymerized hemoglobins. CR Muller, AT Williams, CJ Munoz, AM Eaker, AN Breton, AF Palmer, P Cabrales Transfusion 61 (1), 212-224 14 2021
Control of systemic inflammation through early nitric oxide supplementation with nitric oxide releasing nanoparticles. AT Williams, CR Muller, K Govender, MS Navati, AJ Friedman, P Cabrales Free Radical Biology and Medicine 161, 15-22 26 2020