Pegylated megahemoglobin for use as a red blood cell substitute. (2017-2021) NIH: R01 HL138116 to Andre Palmer. Role: Co-investigator
Next-Generation Polymerized Hemoglobins for Use in Transfusion Medicine . (2017-2020) DOD: W81XWH-18-1-0059 to Andre Palmer. Role: Co-investigator
Noninvasive enteral protease inhibition for the protection against multiorgan failure and death in experimental trauma-hemorrhagic shock (2017-2020). US Army. W81XWH-17-2-0047 to Erik Kistler. Role: Co-investigator
Attenuating the oxidative and myocardial side-effects of acellular hemoglobin (2016-2020). NIH: R01 HL126945 to Andre Palmer. Role: Co-investigator
Attenuating the oxidative and myocardial toxicity of polymerized hemoglobins (2014-2017). NIH R56HL123015 to Andre Palmer. Role: Co-investigator
Blood flow and rheology in the microcirculation (2011-2014). NIH R01-HL052684. to Pedro Cabrales. Role: Investigator
Nitric Oxide Protects Against Microcirculatory Complications of Malaria (2007-2011). NIH: R01 HL087290 to Leonardo Carvalho. Role: Subcontract PI
Nitric oxide quenching by cell-free hemoglobin released as an unavoidable consequence of parasite replication, mediating multiple microcirculatory complications. The proposed studies will also determine tissue oxygenation during malaria pathogenesis. The markedly protected nitric oxide treatment abrogates vascular complications and may lead to adjunct therapy for malaria that rescues millions of people.
Transfusion Trigger Extension by Plasma Expanders (2006 - 2011). NIH/HL: R01 162354 to Marcos Intaglietta. Role: Subcontract PI
The aim of the subcontract is to determine the mechanisms by which high viscosity plasma expanders interact with the endothelial glycocalyx, mediating the production vasoactive factors, such as nitric oxide and prostacylin. These studies are done in vivo with the window chamber and in single isolated vessels.
Bioengineering Design of Artificial Blood (2007 - 2012). NIH/HL: R24 HL64395 to Marcos Intaglietta. Role: Co-investigator
The aim of the project is to develop and optimize oxygen carrier plasma expanders based on polyethylene glycol (PEG) conjugated hemoglobin (Hb), including protein modification to engineer the next generation of blood substitutes.
Active Plasma Expanders Extend the Tolerance to Acute Anemia (2010-2013). U.S. Army: W81XWH Tsai. Role: Co-investigator
The major goal of this project is to determine how polyethylene glycol albumin - a novel class of plasma expanders which enhances microvascular perfusion in hamsters - performs when used as a resuscitation fluid for severe bleeding and hemorrhagic shock in swine. Molecular conformation, microvascular perfusion and survival will be the key parameters followed in these studies.
Plasma Hyperviscosity for the Reversal of Hypovolemic Capillary Collapse (2004-2008). NIH/ARMY: R01 HL076182 to Amy G. Tsai. Role: Scientist
The major goal is to develop high viscosity plasma expanders for use as small volume resuscitation fluids for the treatment of hypovolemic cardiovascular collapse.
Transfusion Trigger Extension by Plasma Expanders (2000 - 2005). NIH/HLBI: R01 HL62354 to Marcos Intaglietta. Role: Scientist
The major goal of the project is to determine the role of blood viscosity in microvascular function in anemic conditions beyond the transfusion trigger.
Microvascular Effects of Surface Decorated Hemoglobin (2002-2008). NIH/HLBI: HL071064 to Joel Friedman. Role: Scientist
The major goal of the project is to understand if shielding of the hemoglobin molecule can affect vasoconstriction.
Development and Implementation of a Children Gait Analysis Laboratory (1999 - 2001). Colombian Government grant to Instituto de OrtopediaInfantilRoosevel, Diana Rincon. Role: Scientist
Design and put into operation a six-camera digital video system to three-dimensionally track eighteen to twenty-five points simultaneously with a passive marker, to be used as a diagnostic tool before and after orthopedic surgery. Calibrate, synchronize and optimize a cinematic modulus and electromyography system to concurrently track position.
Design and Manufacture of Oxygen Carrier Base on Fluorocarbons Emulsions (1999 - 2002). Colombian Government grant to Fundación Cardio-Infantil, Instituto de Cardiología. Juan Carlos Briceno. Role: Scientist
Design laboratory facilities and selection of the equipment. Establish a specific formulation that increases oxygen caring capacity of the plasma when it is used as a plasma expander during transfusion. Run experimental evaluation of the emulsion using different animal models.